NutriStack
Iron Bisglycinate and Omeprazole, a synergy.
Iron bisglycinate is a chelated form of iron whose absorption is less dependent on gastric acid than conventional ferrous sulfate. For patients on omeprazole who need iron repletion, bisglycinate is a more reliable choice and tends to cause less GI upset. It is not an antidote to PPI-induced iron loss, but it minimizes the absorption penalty.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
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At a glance
- Substances
- Iron Bisglycinate and Omeprazole
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Iron bisglycinate is a chelated form of iron whose absorption is less dependent on gastric acid than conventional ferrous sulfate. For patients on omeprazole who need iron repletion, bisglycinate is a more reliable choice and tends to cause less GI upset. It is not an antidote to PPI-induced iron loss, but it minimizes the absorption penalty.
Mechanism. Iron bisglycinate is absorbed intact across enterocytes via amino acid transporters in addition to the standard DMT1 pathway, bypassing the gastric acid step needed to ionize inorganic iron salts. Absorption is therefore more pH-tolerant.
Recommendation. If you take omeprazole and need iron supplementation, choose iron bisglycinate over ferrous sulfate. Take 25-30 mg of elemental iron daily, ideally on an empty stomach, and recheck ferritin in 3 months.
Sources (2)
- Lam JR, Schneider JL, Quesenberry CP, Corley DA. Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency. Gastroenterology. 2017;152(4):821-9. PMID 27890768
- Hamano H, Niimura T, Horinouchi Y, et al. Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 2020;318:86-91. PMID 31669099
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iron Bisglycinate and Omeprazole are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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