NutriStack
L-Glutamine and Saccharomyces Boulardii, a synergy.
L-glutamine and the probiotic yeast Saccharomyces boulardii are often combined for gut barrier and digestive support, acting through complementary mucosal mechanisms.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Glutamine and Saccharomyces Boulardii
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. L-glutamine and the probiotic yeast Saccharomyces boulardii are often combined for gut barrier and digestive support, acting through complementary mucosal mechanisms.
Mechanism. L-glutamine fuels enterocytes and supports tight junctions, while S. boulardii enhances brush-border enzyme activity, trophic polyamine production, and short-chain fatty acid availability that nourish the mucosa.
Recommendation. Reasonable to combine for intestinal support. No timing separation needed.
Sources (2)
- Rao R, Samak G, Role of glutamine in protection of intestinal epithelial tight junctions, Journal of Epithelial Biology and Pharmacology, 2012
- Buts JP, Bernasconi P, Saccharomyces boulardii: basic science and clinical applications in gastroenterology, Gastroenterology Clinics of North America, 2005
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Glutamine and Saccharomyces Boulardii are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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