Interaction databaseSupplement × SupplementReviewed May 2026

L-Theanine and Magnesium Citrate, a synergy.

L-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
L-Theanine and Magnesium Citrate
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. L-theanine and magnesium are both studied for relaxation-related markers, but direct combination evidence is limited.

Mechanism. L-theanine has alpha-wave and glutamate-signaling research, while magnesium participates in NMDA/GABA-related physiology. Clinical evidence for the specific combination is limited.

Recommendation. If combining L-theanine with magnesium citrate, keep total supplemental magnesium within 200-350 mg/day elemental magnesium unless clinician-supervised; do not frame the pair as anxiety treatment.

Sources (2)
  1. Kimura K et al. L-theanine reduces psychological and physiological stress responses. Biol Psychol. 2007
  2. Payne ER, Aceves-Martins M, Dubost J et al.. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Nutrition Reviews. 2025. PMID 40314930

Stack Score

How this pair moves the number.

Effect on the composite score

If both L-Theanine and Magnesium Citrate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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