NutriStack
L-Theanine and Vitamin B6, a synergy.
Both support GABA production. B6 is the cofactor for glutamic acid decarboxylase, which synthesizes GABA. L-theanine increases GABA levels.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- L-Theanine and Vitamin B6
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both support GABA production. B6 is the cofactor for glutamic acid decarboxylase, which synthesizes GABA. L-theanine increases GABA levels.
Mechanism. L-theanine crosses BBB and increases GABA levels directly and via glutamate modulation. B6 (PLP) is the essential cofactor for GAD65/67 enzymes that decarboxylate glutamate to GABA.
Recommendation. Combine for enhanced GABAergic calming support.
Sources (2)
- Nathan PJ et al. The neuropharmacology of L-theanine. J Herb Pharmacother. 2006
- Payne ER, Aceves-Martins M, Dubost J et al.. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. Nutrition Reviews. 2025. PMID 40314930
Stack Score
How this pair moves the number.
Effect on the composite score
If both L-Theanine and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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