NutriStack
Lithium Orotate and Psilocybin, contraindicated.
Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological reactions, making this one of the most dangerous documented psychedelic combinations.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
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At a glance
- Substances
- Lithium Orotate and Psilocybin
- Pair type
- Contraindicated
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Contraindicated · Emerging evidence
Contraindicated
What is happening. Combining psilocybin with lithium has been associated in case reports and online experience reports with seizures and severe adverse neurological reactions, making this one of the most dangerous documented psychedelic combinations.
Mechanism. Lithium appears to lower seizure threshold and alter serotonergic and intracellular signaling in a way that markedly increases the risk of seizures and severe reactions when combined with serotonergic psychedelics.
Recommendation. Do not combine. If you take any lithium-containing product, do not use psilocybin and seek medical advice.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lithium Orotate and Psilocybin are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
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