NutriStack
Iodine and Lithium Orotate, a caution.
Lithium and iodine both affect the thyroid gland, and using them together can increase the likelihood of hypothyroidism or goiter through compounded suppression of thyroid hormone output.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Iodine and Lithium Orotate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Lithium and iodine both affect the thyroid gland, and using them together can increase the likelihood of hypothyroidism or goiter through compounded suppression of thyroid hormone output.
Mechanism. Lithium inhibits thyroid hormone release from the gland, and excess iodine can independently impair hormone synthesis (the Wolff-Chaikoff effect), so together they can additively increase the risk of hypothyroid states.
Recommendation. Use caution when combining. Monitor thyroid function (TSH and free T4) and consult a clinician before pairing lithium orotate with iodine, especially with existing thyroid disease.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iodine and Lithium Orotate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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