NutriStack
Magnesium Citrate and Melatonin, a synergy.
Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Citrate and Melatonin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Melatonin and magnesium are commonly used in sleep routines, but direct stack evidence and optimal dosing vary.
Mechanism. Magnesium participates in neuromuscular and sleep-related physiology; melatonin supports circadian timing. The combination should be presented as routine support, not a sleep-disorder treatment.
Recommendation. If combining melatonin with magnesium citrate, keep magnesium within 200-350 mg/day supplemental elemental magnesium unless clinician-supervised and keep melatonin use situational or clinician-guided for persistent insomnia.
Sources (1)
- Abbasi B et al. The effect of magnesium supplementation on primary insomnia in elderly. J Res Med Sci. 2012
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Citrate and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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