NutriStack
MAOIs and Tyramine / High-Tyramine Foods, contraindicated.
Irreversible MAO inhibitors can sharply reduce tyramine breakdown. High-tyramine foods can then trigger sudden, severe blood-pressure elevation and hypertensive crisis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
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At a glance
- Substances
- MAOIs and Tyramine / High-Tyramine Foods
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Irreversible MAO inhibitors can sharply reduce tyramine breakdown. High-tyramine foods can then trigger sudden, severe blood-pressure elevation and hypertensive crisis.
Mechanism. MAO-A normally metabolizes dietary tyramine. When MAO-A is inhibited, tyramine can provoke excessive norepinephrine release and dangerous blood-pressure elevation.
Recommendation. Avoid high-tyramine foods while taking irreversible MAOIs and continue the MAOI diet for the prescriber-recommended washout period after stopping.
Stack Score
How this pair moves the number.
Effect on the composite score
If both MAOIs and Tyramine / High-Tyramine Foods are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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