NutriStack
Selegiline and Tyramine / High-Tyramine Foods, contraindicated.
Selegiline can act as a monoamine oxidase inhibitor depending on formulation and dose. Systemic or higher-dose MAOI exposure can reduce tyramine breakdown, so high-tyramine foods may trigger sudden, severe blood-pressure elevation and hypertensive crisis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Selegiline and Tyramine / High-Tyramine Foods
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Selegiline can act as a monoamine oxidase inhibitor depending on formulation and dose. Systemic or higher-dose MAOI exposure can reduce tyramine breakdown, so high-tyramine foods may trigger sudden, severe blood-pressure elevation and hypertensive crisis.
Mechanism. MAO-A normally metabolizes dietary tyramine. When MAO-A is substantially inhibited, tyramine can provoke excessive norepinephrine release and dangerous blood-pressure elevation; selegiline selectivity varies by dose and formulation.
Recommendation. Follow the prescriber-specific tyramine restrictions for your selegiline formulation and dose. Avoid high-tyramine foods whenever MAOI dietary restrictions apply.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Selegiline and Tyramine / High-Tyramine Foods are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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