NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Phenelzine and Tyramine / High-Tyramine Foods: what the published research says

PubMed indexes 7 records that name Phenelzine and Tyramine / High-Tyramine Foods together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Phenelzine and Tyramine / High-Tyramine Foods. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

7 studies naming Phenelzine and Tyramine / High-Tyramine Foods.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Monoamine oxidase inhibition by phenelzine and brofaromine in healthy volunteers.

Clinical pharmacology and therapeutics · 1989 · PMID 2920501

Comparative StudyHuman subjects

“The nonsignificant decrease of MHPG excretion and the increase of intravenous tyramine pressor sensitivity caused by phenelzine are significantly related. The data suggest that the selective reversible MAO-A inhibitor brofaromine has a larger therapeutic safety than phenelzine.”

Bieck et al. · From the abstract

Names Phenelzine and Tyramine / High-Tyramine Foods together in an interaction, co-administration, or pharmacokinetic context.

Preclinical profiles of the novel reversible MAO-A inhibitors, moclobemide and brofaromine, in comparison with irreversible MAO inhibitors.

Journal of neural transmission. Supplementum · 1989 · PMID 2677242

Comparative StudyReviewHuman subjects

“Results from preclinical and clinical investigations demonstrate that moclobemide and brofaromine, in contrast to tranylcypromine and phenelzine, very weakly potentiate the pressor effects of orally administered tyramine. In conclusion, the reversible MAO-A inhibitors moclobemide and brofaromine, due to their well-documented safety characteristics, to their lack of anticholinergic-effects and to their good tolerability, will provide innovative tools for clarifying the role…”

Da Prada et al. · From the abstract

Names Phenelzine and Tyramine / High-Tyramine Foods together in an interaction, co-administration, or pharmacokinetic context.

Hypertensive crises with reversible inhibitors of monoamine oxidases? Results of tyramine interaction studies

Psychiatrische Praxis · 1989 · PMID 2587674

Comparative StudyHuman subjects

“The increased sensitivity after phenelzine persisted for longer than 8 weeks and after clorgyline for longer than 15 weeks. The results suggest that the two reversible MAO-A inhibitors moclobemide and brofaromine carry a much reduced liability to tyramine-related hypertensive reactions.”

Bieck · From the abstract

Names Phenelzine and Tyramine / High-Tyramine Foods together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Phenelzine, Tyramine / High-Tyramine Foods, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.