Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep.
Clinical TrialRandomized Controlled TrialResearch Support, U.S. Gov't, Non-P.H.S.
Names both L-Tryptophan and Phenelzine in its title.
Supplement × Prescription·Evidence index
PubMed indexes 7 records that name L-Tryptophan and Phenelzine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.
A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.
Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.
“Three cases are presented on patients on an MAOI who developed a transient syndrome of myoclonus, hyperreflexia, jaw quivering, teeth chattering and diaphoresis after L-Tryptophan was added. Caution is advised when considering the addition of a serotonergic agent to MAOI's.”
“The addition of tryptophan to a monoamine oxidase inhibitor (MAOI) has been recommended for patients failing to respond to an MAOI alone. The authors report acute behavioral and neurologic toxicity immediately after tryptophan administration in a patient taking phenelzine.”
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both L-Tryptophan and Phenelzine in its title.
“Three cases are presented on patients on an MAOI who developed a transient syndrome of myoclonus, hyperreflexia, jaw quivering, teeth chattering and diaphoresis after L-Tryptophan was added. Caution is advised when considering the addition of a serotonergic agent to MAOI's.”
Names both L-Tryptophan and Phenelzine in its title.
“The addition of tryptophan to a monoamine oxidase inhibitor (MAOI) has been recommended for patients failing to respond to an MAOI alone. The authors report acute behavioral and neurologic toxicity immediately after tryptophan administration in a patient taking phenelzine.”
Names both L-Tryptophan and Phenelzine in its title.
Names both L-Tryptophan and Phenelzine in its title.
“1 Uptake of 5-hydroxytryptamine in the catecholamine containing nerve endings of the hypothalamus in the rat brain was found after intraperitoneal injection of phenelzine sulphate (25 mg/kg) and tryptophan (100 and 400 mg/kg). 2 The results were obtained by fluorescence microscopy and microspectrofluorimetry.”
Names both L-Tryptophan and Phenelzine in its title.
Names both L-Tryptophan and Phenelzine in its title.
Names L-Tryptophan and Phenelzine together in an interaction, co-administration, or pharmacokinetic context.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers L-Tryptophan, Phenelzine, and several hundred other substances.
Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.