NutriStack
Methylfolate and Zinc, a caution.
High-dose zinc (>40mg) may impair folate absorption by inhibiting the folate conjugase enzyme in the gut.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Methylfolate and Zinc
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. High-dose zinc (>40mg) may impair folate absorption by inhibiting the folate conjugase enzyme in the gut.
Mechanism. Zinc at high doses may inhibit pteroylpolyglutamate hydrolase (folate conjugase), the brush-border enzyme that deconjugates dietary polyglutamyl folates to the absorbable monoglutamyl form.
Recommendation. If taking high-dose zinc, monitor folate status or separate doses.
Minimum separation. 120
Sources (1)
- Ghishan FK et al. Effect of zinc on intestinal folate absorption. Am J Physiol. 1986
Stack Score
How this pair moves the number.
Effect on the composite score
If both Methylfolate and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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