NutriStack
Methylprednisolone and Vitamin D2, a synergy.
Chronic methylprednisolone exposure can reduce bone density and raise fracture risk. Vitamin D2 can help maintain vitamin D status and calcium absorption, which are core parts of glucocorticoid-induced osteoporosis prevention.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Methylprednisolone and Vitamin D2
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Chronic methylprednisolone exposure can reduce bone density and raise fracture risk. Vitamin D2 can help maintain vitamin D status and calcium absorption, which are core parts of glucocorticoid-induced osteoporosis prevention.
Mechanism. Systemic glucocorticoids suppress bone formation, increase bone resorption, and impair calcium balance. Vitamin D2 increases 25-OH vitamin D availability and supports calcium absorption.
Recommendation. If methylprednisolone is used beyond a short course, maintain vitamin D status and ask whether bone density testing or prescription osteoporosis prevention is appropriate. Vitamin D2 should complement calcium intake and risk-based treatment decisions, not replace them.
Sources (2)
- Humphrey MB, Russell L, Danila MI, et al. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Care Res (Hoboken). 2023;75(12):2405-2419. PMID 37884467
- Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;1998(2):CD000952. PMID 10796394
Stack Score
How this pair moves the number.
Effect on the composite score
If both Methylprednisolone and Vitamin D2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.