Supplement × Prescription·a caution·Moderate evidence
St. John's Wort is an inducer of CYP3A4 and P-glycoprotein. Oxcarbazepine also induces CYP3A4, so the combination can amplify interaction burden for other medications.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort is an inducer of CYP3A4 and P-glycoprotein. Oxcarbazepine also induces CYP3A4, so the combination can amplify interaction burden for other medications.
Mechanism. Additive enzyme and transporter induction can lower exposure to susceptible co-medications.
Recommendation. Avoid unless the clinician has reviewed all medications, especially hormonal contraceptives, anticoagulants, immunosuppressants, and psychiatric drugs.
Effect on the composite score
If both Oxcarbazepine and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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