NutriStack
Probiotics and Terbinafine, a synergy.
Oral terbinafine treats fungal infections but its mycobiome and microbiome impact in humans is incompletely characterized, and antifungal exposure in animal models alters fungal and bacterial gut communities. Probiotic strains such as Lactobacillus and Saccharomyces boulardii have anti-Candida and barrier-supportive effects that may help restore balance after a long oral antifungal course.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Probiotics and Terbinafine
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Oral terbinafine treats fungal infections but its mycobiome and microbiome impact in humans is incompletely characterized, and antifungal exposure in animal models alters fungal and bacterial gut communities. Probiotic strains such as Lactobacillus and Saccharomyces boulardii have anti-Candida and barrier-supportive effects that may help restore balance after a long oral antifungal course.
Mechanism. Antifungal exposure can shift fungal and bacterial gut populations. Probiotics compete with pathogens for adhesion sites, secrete antimicrobial metabolites (e.g., capric acid from S. boulardii inhibits Candida), and modulate mucosal immunity.
Recommendation. If you want to use probiotics during or after a terbinafine course, choose a well-studied strain. Take Saccharomyces boulardii only after the antifungal course is complete, since terbinafine has limited activity against yeasts and S. boulardii is itself a yeast.
Sources (2)
- Seelbinder B, et al. Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome. 2020;8(1):133. PMID 32451559
- Suchodolski J, et al. Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B. Sci Rep. 2021;11(1):6519. PMID 33753842
Stack Score
How this pair moves the number.
Effect on the composite score
If both Probiotics and Terbinafine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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