What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the NAC + Terbinafine pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

NAC and Terbinafine, a synergy.

Q: Can I take NAC and Terbinafine together?

Yes. The combination of NAC and Terbinafine produces a measurable benefit. Terbinafine is metabolized to a reactive allylic aldehyde (TBF-A) thought to drive its idiosyncratic hepatotoxicity. N-acetylcysteine restores glutathione and has been used in non-acetaminophen drug-induced liver injury. The combination is not a proven prophylactic but is a low-risk adjunct in higher-risk patients on multi-month courses.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Terbinafine is metabolized to a reactive allylic aldehyde (TBF-A) thought to drive its idiosyncratic hepatotoxicity. N-acetylcysteine restores glutathione and has been used in non-acetaminophen drug-induced liver injury. The combination is not a proven prophylactic but is a low-risk adjunct in higher-risk patients on multi-month courses.

2 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: NAC and Terbinafine
Pair type: Synergy
Evidence (highest tier): Emerging
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Terbinafine is metabolized to a reactive allylic aldehyde (TBF-A) thought to drive its idiosyncratic hepatotoxicity. N-acetylcysteine restores glutathione and has been used in non-acetaminophen drug-induced liver injury. The combination is not a proven prophylactic but is a low-risk adjunct in higher-risk patients on multi-month courses.

Mechanism. NAC replenishes glutathione, which detoxifies reactive metabolites such as terbinafine's TBF-A intermediate.

Recommendation. Do not rely on NAC instead of routine liver enzyme monitoring. If you have additional hepatotoxicity risk factors, discuss adjunctive NAC with your prescriber.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both NAC and Terbinafine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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