What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Pterostilbene + Vitamin B12 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Insufficient evidence

Pterostilbene + Vitamin B12

Q: Can I take Pterostilbene and Vitamin B12 together?

Yes. The combination of Pterostilbene and Vitamin B12 produces a measurable benefit. Pterostilbene is frequently paired with NAD precursors to support sirtuin activity. Methyl-group sufficiency, supported by B12 and folate, becomes relevant during this kind of methylation-intensive supplementation, making adequate B12 status supportive of overall methyl balance.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Insufficient evidence

Pterostilbene is frequently paired with NAD precursors to support sirtuin activity. Methyl-group sufficiency, supported by B12 and folate, becomes relevant during this kind of methylation-intensive supplementation, making adequate B12 status supportive of overall methyl balance.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Pterostilbene and Vitamin B12

Pair type

Synergy

Evidence

Insufficient

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyInsufficient evidence

What is happening. Pterostilbene is frequently paired with NAD precursors to support sirtuin activity. Methyl-group sufficiency, supported by B12 and folate, becomes relevant during this kind of methylation-intensive supplementation, making adequate B12 status supportive of overall methyl balance.

Mechanism. Pterostilbene is metabolized partly via methylation pathways, and stacks built around NAD and sirtuin activation draw on the methyl pool. B12 supports methionine synthase and S-adenosylmethionine regeneration, helping sustain methyl-group availability.

Recommendation. Maintain adequate B12 status when running methylation-relevant longevity stacks. No special separation is required; take with food.

Stack Score

How it moves the number.

Effect on the composite score

If both Pterostilbene and Vitamin B12 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Riche DM, et al. Analysis of safety from a human clinical trial with pterostilbene. J Toxicol. 2013.Needs sourceNo link

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