What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Pterostilbene + Quercetin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Emerging evidence

Pterostilbene + Quercetin

Q: Can I take Pterostilbene and Quercetin together?

Yes, if you separate them in time. Pterostilbene and Quercetin have a documented timing-sensitive interaction. Quercetin inhibits several CYP450 enzymes and the efflux transporter P-glycoprotein. Co-administration could alter the metabolism and plasma levels of pterostilbene, which undergoes phase II conjugation, potentially increasing its exposure.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Quercetin inhibits several CYP450 enzymes and the efflux transporter P-glycoprotein. Co-administration could alter the metabolism and plasma levels of pterostilbene, which undergoes phase II conjugation, potentially increasing its exposure.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Pterostilbene and Quercetin

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Quercetin inhibits several CYP450 enzymes and the efflux transporter P-glycoprotein. Co-administration could alter the metabolism and plasma levels of pterostilbene, which undergoes phase II conjugation, potentially increasing its exposure.

Mechanism. Quercetin inhibits CYP3A4, sulfotransferases, UDP-glucuronosyltransferases, and P-glycoprotein, which can reduce first-pass conjugation of pterostilbene and increase its systemic exposure.

Recommendation. If taking both regularly, consider separating doses and start at modest amounts. Be aware that quercetin may raise pterostilbene levels and the levels of co-administered medications metabolized by the same enzymes.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Pterostilbene and Quercetin are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Lin HS, et al. Pharmacokinetics of pterostilbene in rats. J Pharm Pharmacol. 2009.Needs sourceNo link

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Open the interaction checker → Browse the research index