From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Both are used for hormone-related goals and may complicate assessment of breast, menstrual, prostate, or endocrine symptoms.
Mechanism. Overlapping endocrine-targeted supplement use with limited combined safety data.
Recommendation. Avoid unsupervised hormone-active stacking; stop and seek care for bleeding, breast changes, or prostate red flags.
Stack Score
How it moves the number.
Effect on the composite score
If both Pueraria Mirifica and Saw Palmetto are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Manonai J et al. Pueraria mirifica systematic review. Journal of Ethnopharmacology. 2018.Needs sourceNo link