From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Ginkgo can increase bleeding tendency, and estrogenic botanicals can cause abnormal bleeding in susceptible users.
Mechanism. Potential additive bleeding concern and masking of estrogenic adverse effects.
Recommendation. Avoid high-dose combination before surgery or in unexplained bleeding; seek care for vaginal bleeding after menopause.
Stack Score
How it moves the number.
Effect on the composite score
If both Ginkgo Biloba and Pueraria Mirifica are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Manonai J et al. Pueraria mirifica clinical safety review. Journal of Ethnopharmacology. 2018.Needs sourceNo link