Supplement × Supplement·a caution·Emerging evidence
St. John's Wort may alter metabolism of many drugs and hormone therapies, making estrogenic supplement effects harder to predict.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort may alter metabolism of many drugs and hormone therapies, making estrogenic supplement effects harder to predict.
Mechanism. CYP and P-glycoprotein induction by St. John's Wort plus estrogenic activity from Pueraria mirifica.
Recommendation. Avoid combining when using hormonal contraception, hormone therapy, anti-estrogen drugs, or prescription medications without clinician review.
Effect on the composite score
If both Pueraria Mirifica and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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