NutriStack
Rivaroxaban and Turmeric/Curcumin, a caution.
Curcumin has antiplatelet properties that may increase bleeding risk when combined with rivaroxaban. The additive effect on hemostasis through different mechanisms (antiplatelet + anticoagulant) poses a theoretical and potentially clinical risk of enhanced bleeding.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Rivaroxaban and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Curcumin has antiplatelet properties that may increase bleeding risk when combined with rivaroxaban. The additive effect on hemostasis through different mechanisms (antiplatelet + anticoagulant) poses a theoretical and potentially clinical risk of enhanced bleeding.
Mechanism. Curcumin inhibits platelet aggregation via thromboxane A2 suppression and calcium signaling blockade. Combined with rivaroxaban's Factor Xa inhibition, the dual impact on coagulation and platelet function increases bleeding risk.
Recommendation. Use low-dose curcumin cautiously with rivaroxaban. Avoid high-dose curcumin supplements. Monitor for signs of unusual bleeding or bruising.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Rivaroxaban and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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