NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Rivaroxaban

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Rivaroxaban is a direct factor Xa inhibitor approved for stroke prevention in non-valvular atrial fibrillation, DVT/PE treatment and prevention, and secondary cardiovascular prevention (with aspirin in COMPASS trial). The ROCKET AF trial demonstrated non-inferiority to warfarin for stroke prevention in AF.

Evidence tier
Strong
Indexed sources
10 2012–2026
Interactions
0
Category
Prescription
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Rivaroxaban is a direct factor Xa inhibitor approved for stroke prevention in non-valvular atrial fibrillation, DVT/PE treatment and prevention, and secondary cardiovascular prevention (with aspirin in COMPASS trial). NutriStack rates the supporting evidence as strong. Common adult dosing is AF: 20 mg once daily with evening meal; DVT/PE: 15 mg twice daily for 21 days, then 20 mg daily; Vascular prevention: 2.5 mg twice daily with aspirin (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 10 sources.

What it's good for
  • Non-inferior to warfarin for stroke prevention in AF (ROCKET AF)1,4
  • Once-daily dosing for most indications
  • No routine monitoring required
  • Reduces cardiovascular events when combined with aspirin (COMPASS)8,5
What to watch for
  • Bleeding (major and clinically relevant non-major)
  • Bruising
  • GI bleeding (higher rate than warfarin in ROCKET AF)
  • Active pathological bleeding6
  • Severe hypersensitivity to rivaroxaban1,2

The bottom line

Evidence rating strong. Most-documented uses: non-inferior to warfarin for stroke prevention in af (rocket af), once-daily dosing for most indications, no routine monitoring required. 10 sources indexed (2012–2026), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Directly and selectively inhibits free and clot-bound factor Xa. Inhibition of factor Xa interrupts the intrinsic and extrinsic coagulation pathways, reducing thrombin generation and thrombus formation. High oral bioavailability and predictable pharmacokinetics. Partially renally eliminated (~33%).

Class
Direct Oral Anticoagulant (DOAC)
Absorption
Water-soluble; take with food
Dosing

Dosing & protocol.

Common range
AF: 20 mg once daily with evening meal; DVT/PE: 15 mg twice daily for 21 days, then 20 mg daily; Vascular prevention: 2.5 mg twice daily with aspirin (as prescribed by your physician)
Recommended form
Oral tablet, taken with food for 15 mg and 20 mg doses

15 mg and 20 mg doses MUST be taken with food to ensure adequate absorption (bioavailability increases from 66% to near 100%); 10 mg dose can be taken with or without food9

Safety

Full safety detail.

Side effects

  • Bleeding (major and clinically relevant non-major)
  • Bruising
  • GI bleeding (higher rate than warfarin in ROCKET AF)
  • Epistaxis
  • Anemia
  • Nausea

Contraindications

  • Active pathological bleeding6
  • Severe hypersensitivity to rivaroxaban1,2
  • Prosthetic heart valves (not recommended)
  • Triple-positive antiphospholipid syndrome
  • Moderate or severe hepatic impairment (Child-Pugh B or C)
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

5

Randomized controlled trials

1

Reference material

4
FAQ

Common questions.

Quick answers about Rivaroxaban, drawn from the data on this page.

What is Rivaroxaban?

Rivaroxaban is a direct factor Xa inhibitor approved for stroke prevention in non-valvular atrial fibrillation, DVT/PE treatment and prevention, and secondary cardiovascular prevention (with aspirin in COMPASS trial). The ROCKET AF trial demonstrated non-inferiority to warfarin for stroke prevention in AF.

What is Rivaroxaban used for?

Commonly cited benefits of Rivaroxaban include: Non-inferior to warfarin for stroke prevention in AF (ROCKET AF); Once-daily dosing for most indications; No routine monitoring required; Reduces cardiovascular events when combined with aspirin (COMPASS). NutriStack rates the overall evidence as strong.

What is a typical dose of Rivaroxaban?

A typical adult dose of Rivaroxaban is AF: 20 mg once daily with evening meal; DVT/PE: 15 mg twice daily for 21 days, then 20 mg daily; Vascular prevention: 2.5 mg twice daily with aspirin (as prescribed by your physician). The commonly recommended form is Oral tablet, taken with food for 15 mg and 20 mg doses. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Rivaroxaban?

Reported side effects include bleeding (major and clinically relevant non-major), bruising, gi bleeding (higher rate than warfarin in rocket af), epistaxis, anemia, nausea. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Rivaroxaban?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Rivaroxaban in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.