NutriStack
Garlic Extract and Rivaroxaban, a caution.
Concentrated garlic extracts inhibit platelet aggregation and have been linked to perioperative bleeding. Added to rivaroxaban's factor Xa inhibition, the antiplatelet activity raises bleeding risk. Dietary garlic is not a concern.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Garlic Extract and Rivaroxaban
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Concentrated garlic extracts inhibit platelet aggregation and have been linked to perioperative bleeding. Added to rivaroxaban's factor Xa inhibition, the antiplatelet activity raises bleeding risk. Dietary garlic is not a concern.
Mechanism. Allicin and related organosulfur compounds inhibit platelet arachidonic acid metabolism, modify platelet membrane properties, and interfere with calcium signalling, reducing aggregation. This is additive to rivaroxaban's factor Xa blockade.
Recommendation. Avoid concentrated garlic supplements (aged garlic extract, allicin capsules) while on rivaroxaban, and stop them at least 7 days before any planned surgery. Cooking with garlic is fine.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Garlic Extract and Rivaroxaban are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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