Supplement × Supplement·a caution·Moderate evidence
St. John's Wort is serotonergic and a strong CYP/P-gp inducer; combining with saffron complicates psychiatric and drug-interaction risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort is serotonergic and a strong CYP/P-gp inducer; combining with saffron complicates psychiatric and drug-interaction risk.
Mechanism. Additive serotonergic activity plus St. John's Wort enzyme induction.
Recommendation. Avoid routine combination, especially with antidepressants, hormonal contraception, anticoagulants, or transplant medications.
Effect on the composite score
If both Saffron Extract and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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