NutriStack
Saw Palmetto and Zinc, a synergy.
Saw palmetto and zinc are a classic prostate-support pairing that target the same hormonal pathway, giving additive support within benign prostatic hyperplasia (BPH) symptom protocols.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Saw Palmetto and Zinc
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Saw palmetto and zinc are a classic prostate-support pairing that target the same hormonal pathway, giving additive support within benign prostatic hyperplasia (BPH) symptom protocols.
Mechanism. Saw palmetto inhibits 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT) in prostate tissue, while zinc concentrates in the prostate where it supports normal glandular function and may modestly modulate 5-alpha reductase activity.
Recommendation. Reasonable to combine. Typical doses are saw palmetto 320 mg/day and zinc 15 to 30 mg/day, with copper 1 to 2 mg added on prolonged high-dose zinc to prevent copper depletion.
Sources (2)
- Suzuki M et al, Saw palmetto extract suppresses 5-alpha reductase activity, Journal of Ethnopharmacology, 2009
- Costello LC, Franklin RB, The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression, Molecular Cancer, 2006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Saw Palmetto and Zinc are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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