NutriStack
Statins and Tribulus Terrestris, a caution.
Tribulus terrestris is a moderate CYP3A4 inhibitor. Documented rhabdomyolysis in patient on atorvastatin who started tribulus.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Statins and Tribulus Terrestris
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Tribulus terrestris is a moderate CYP3A4 inhibitor. Documented rhabdomyolysis in patient on atorvastatin who started tribulus.
Mechanism. CYP3A4 inhibition increases statin blood levels, raising risk of myopathy and rhabdomyolysis.
Recommendation. Avoid combining with CYP3A4-metabolized statins (atorvastatin, simvastatin, lovastatin).
Sources (1)
- Tribulus rhabdomyolysis with statin PMID 39012853
Stack Score
How this pair moves the number.
Effect on the composite score
If both Statins and Tribulus Terrestris are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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