Interaction databaseSupplement × SupplementReviewed May 2026

Vitamin C Liposomal and Vitamin E, a synergy.

Vitamin C Liposomal regenerates vitamin E from its oxidized tocopheroxyl radical form, extending its antioxidant capacity.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Vitamin C Liposomal and Vitamin E
Pair type
Synergy
Evidence (highest tier)
Strong
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Vitamin C Liposomal regenerates vitamin E from its oxidized tocopheroxyl radical form, extending its antioxidant capacity.

Mechanism. Ascorbate donates an electron to the tocopheroxyl radical at the membrane-cytosol interface, regenerating alpha-tocopherol and extending its chain-breaking antioxidant activity.

Recommendation. Take together for optimal antioxidant protection. Vitamin C Liposomal recycles vitamin E in cell membranes.

Sources (2)
  1. Traber MG, Stevens JF. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med. 2011
  2. Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2024. PMID 38820340

Stack Score

How this pair moves the number.

Effect on the composite score

If both Vitamin C Liposomal and Vitamin E are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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