NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Activated Charcoal and Dapsone: what the published research says

PubMed indexes 6 records that name Activated Charcoal and Dapsone together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Activated Charcoal and Dapsone. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Activated Charcoal and Dapsone.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Repetitive doses of activated charcoal in Dapsone poisoning in a child.

Journal of toxicology. Clinical toxicology · 1982 · PMID 7184998

Case ReportsHuman subjects

“This rapid improvement is attributed to interruption by activated charcoal of the enterohepatic circulation of Dapsone. This mode of therapy may be indicated for other compounds having an enterohepatic circulation.”

Reigart et al. · From the abstract

Names both Activated Charcoal and Dapsone in its title.

Oral activated charcoal and dapsone elimination.

Clinical pharmacology and therapeutics · 1980 · PMID 7379451

Clinical TrialRandomized Controlled Trial

“The use of activated charcoal, 80 gm/day for 1 or 2 days, increased (3 to 5 times) the rate of elimination of both dapsone and MADDS, as reflected in serum concentration and urinary excretion data. The use of multiple doses of charcoal seems to be indicated as supplementary treatment of certain intoxications during the postabsorption phase if the drugs have a long t 1/2 and if they are secreted into the gut with subsequent reabsorption.”

Neuvonen et al. · From the abstract

Names both Activated Charcoal and Dapsone in its title.

Acute dapsone exposure and methemoglobinemia in children: treatment with multiple doses of activated charcoal with or without the administration of methylene blue

Jornal de pediatria · 2000 · PMID 14647658

17 participants

“Twelve of the 14 patients with methemoglobin levels greater than 30% were also treated with a single dose of methylene blue (1-2% solution, 1-2 mg/kg) infused IV over 5 min.RESULTS: There was a progressive decrease in the methemoglobin levels after the beginning of both treatments (multiple doses of activated charcoal alone or associated with methylene blue), and only one dose of methylene blue was necessary.”

Bucaretchi et al. · From the abstract

Names both Activated Charcoal and Dapsone in its title.

Treatment of a life-threatening dapsone intoxication.

Toxicology reports · 2023 · PMID 37868805

Case Reports

“Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient.”

Veerman et al. · From the abstract

Names Activated Charcoal and Dapsone together in an interaction, co-administration, or pharmacokinetic context.

Extracorporeal treatments in a dapsone overdose: a case report.

Clinical toxicology (Philadelphia, Pa.) · 2016 · PMID 27424534

Case ReportsHuman subjects

“Dapsone clearance was enhanced by ECTR, especially by IHD-HP. However, HP was associated with severe asymptomatic thrombocytopenia.”

Ghannoum et al. · From the abstract

Names Activated Charcoal and Dapsone together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Activated Charcoal, Dapsone, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.