NutriStack
Activated Charcoal and Dapsone, timing-sensitive.
Activated charcoal can bind dapsone in the gut and can also accelerate elimination by interrupting enterohepatic or enteroenteric recirculation. This is useful in overdose under medical supervision, but routine charcoal supplementation can lower therapeutic dapsone exposure and may worsen disease control. Repeated charcoal doses are more concerning than a single isolated dose.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Activated Charcoal and Dapsone
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Activated charcoal can bind dapsone in the gut and can also accelerate elimination by interrupting enterohepatic or enteroenteric recirculation. This is useful in overdose under medical supervision, but routine charcoal supplementation can lower therapeutic dapsone exposure and may worsen disease control. Repeated charcoal doses are more concerning than a single isolated dose.
Mechanism. Activated charcoal adsorbs dapsone in the gastrointestinal tract and can increase dapsone clearance by interrupting gut recirculation. Dapsone has a long half-life and enterohepatic circulation, making it particularly susceptible to multidose charcoal effects.
Recommendation. Do not take activated charcoal routinely while using oral dapsone unless poison control or your clinician tells you to. If you take charcoal for a non-emergency reason, separate it from dapsone by at least 4 hours and tell your prescriber if you use it repeatedly. In overdose or suspected toxicity, seek emergency care rather than self-treating.
Minimum separation. 240
Stack Score
How this pair moves the number.
Effect on the composite score
If both Activated Charcoal and Dapsone are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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