NutriStack
Alpha-Lipoic Acid and Berberine, a synergy.
Both improve insulin sensitivity through AMPK activation. ALA also supports glucose uptake via GLUT4 translocation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and Berberine
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both improve insulin sensitivity through AMPK activation. ALA also supports glucose uptake via GLUT4 translocation.
Mechanism. Berberine activates AMPK via mitochondrial Complex I inhibition. ALA activates AMPK via CaMKK pathway and enhances insulin-stimulated glucose uptake by promoting GLUT4 translocation.
Recommendation. Combine for enhanced metabolic support. Monitor blood glucose if combining with diabetes medications.
Sources (1)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Berberine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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