Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol, a synergy.
Both support mitochondrial function. CoQ10 is essential for the electron transport chain; ALA is a cofactor for mitochondrial dehydrogenases.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both support mitochondrial function. CoQ10 is essential for the electron transport chain; ALA is a cofactor for mitochondrial dehydrogenases.
Mechanism. CoQ10 shuttles electrons in the ETC (Complex I→III). ALA is a cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase in the TCA cycle. Together they optimize mitochondrial energy production.
Recommendation. Combine for comprehensive mitochondrial support, especially for cardiovascular and neurological health.
Sources (1)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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