Interaction databaseSupplement × SupplementReviewed May 2026

Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol, a synergy.

Both support mitochondrial function. CoQ10 is essential for the electron transport chain; ALA is a cofactor for mitochondrial dehydrogenases.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
1 source
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Both support mitochondrial function. CoQ10 is essential for the electron transport chain; ALA is a cofactor for mitochondrial dehydrogenases.

Mechanism. CoQ10 shuttles electrons in the ETC (Complex I→III). ALA is a cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase in the TCA cycle. Together they optimize mitochondrial energy production.

Recommendation. Combine for comprehensive mitochondrial support, especially for cardiovascular and neurological health.

Sources (1)
  1. Singh U et al. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008;66(11):646-57. PMID 19019027

Stack Score

How this pair moves the number.

Effect on the composite score

If both Alpha-Lipoic Acid and Coenzyme Q10 Ubiquinol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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