From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Alpha-lipoic acid can lower glucose and is used for mitochondrial redox claims, complicating adverse-effect attribution.
Mechanism. Overlapping metabolic and redox effects.
Recommendation. Use only with clinician awareness in mitochondrial protocols.
Stack Score
How it moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Elamipretide (SS-31) are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Karaa A et al. Elamipretide crossover trial. J Cachexia Sarcopenia Muscle. 2020.Needs sourceNo link