From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Alpha-lipoic acid affects glucose handling and oxidative stress, complicating interpretation of humanin effects.
Mechanism. Overlapping metabolic and redox effects.
Recommendation. Avoid unapproved mitochondrial stacks without clinician review.
Stack Score
How it moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Humanin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Zuccato CF et al. Humanin therapeutic target review. 2019.Needs sourceNo link