What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the American Ginseng + St. John's Wort pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a caution·Emerging evidence

American Ginseng + St. John's Wort

Q: Can I take American Ginseng and St. John's Wort together?

Possibly, but with caution. American Ginseng and St. John's Wort have a documented caution-tier interaction. St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein and may accelerate the metabolism of ginsenosides, potentially reducing the effectiveness of American ginseng.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein and may accelerate the metabolism of ginsenosides, potentially reducing the effectiveness of American ginseng.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

American Ginseng and St. John's Wort

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. St. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein and may accelerate the metabolism of ginsenosides, potentially reducing the effectiveness of American ginseng.

Mechanism. St. John's Wort hyperforin activates the pregnane X receptor, inducing CYP3A4 and P-glycoprotein, which can increase first-pass metabolism and efflux of ginsenosides and lower their systemic exposure.

Recommendation. Be aware that concurrent St. John's Wort may blunt the expected effects of American ginseng. Separating doses does not overcome enzyme induction; consider this when judging efficacy.

Stack Score

How it moves the number.

Effect on the composite score

If both American Ginseng and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Borrelli F, Izzo AA. Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations. AAPS J. 2009.Needs sourceNo link

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