NutriStack
Amiodarone and Escitalopram, a caution.
Both amiodarone and escitalopram can prolong the QT interval. Combined use increases the risk of dangerous cardiac arrhythmias, particularly torsades de pointes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amiodarone and Escitalopram
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both amiodarone and escitalopram can prolong the QT interval. Combined use increases the risk of dangerous cardiac arrhythmias, particularly torsades de pointes.
Mechanism. Additive QT prolongation through independent hERG potassium channel blockade by both agents.
Recommendation. Monitor ECG closely if combined. Consider alternative antidepressant with lower QT prolongation risk (e.g., sertraline). Keep electrolytes balanced.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amiodarone and Escitalopram are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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