NutriStack
Aspirin Low-Dose and Vitamin E, a caution.
High-dose vitamin E may increase bleeding tendency and could add to low-dose aspirin's antiplatelet effect. Vitamin E supplementation has been shown to affect vitamin K status, and randomized-trial meta-analysis links vitamin E with increased hemorrhagic stroke risk. The concern is mainly with high-dose supplements rather than usual dietary vitamin E.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Aspirin Low-Dose and Vitamin E
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. High-dose vitamin E may increase bleeding tendency and could add to low-dose aspirin's antiplatelet effect. Vitamin E supplementation has been shown to affect vitamin K status, and randomized-trial meta-analysis links vitamin E with increased hemorrhagic stroke risk. The concern is mainly with high-dose supplements rather than usual dietary vitamin E.
Mechanism. Vitamin E can interfere with vitamin K-dependent coagulation biology and may affect platelet function at high doses. Aspirin irreversibly inhibits platelet COX-1, creating additive bleeding potential.
Recommendation. Avoid high-dose vitamin E while taking low-dose aspirin unless your clinician recommends it. Keep supplemental vitamin E modest and report unusual bruising, nosebleeds, black stools, or neurologic symptoms promptly.
Sources (2)
- Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, Hamada K, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr. 2004;80(1):143-148. PMID 15213041
- Schurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ. 2010;341:c5702. PMID 21051774
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin Low-Dose and Vitamin E are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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