Interaction databaseSupplement × SupplementReviewed May 2026

Bee Pollen and Royal Jelly, a caution.

Bee pollen and royal jelly are both bee-derived products that can trigger allergic reactions, and taking them together increases cumulative exposure to bee allergens and the risk of a serious reaction.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Bee Pollen and Royal Jelly
Pair type
Caution
Evidence (highest tier)
Moderate
Source citations
2 sources
Stack Score effect
−5 to your Stack Score (per scored caution row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Bee pollen and royal jelly are both bee-derived products that can trigger allergic reactions, and taking them together increases cumulative exposure to bee allergens and the risk of a serious reaction.

Mechanism. Both products contain bee-derived proteins and pollen allergens capable of provoking IgE-mediated hypersensitivity, and combined intake raises total allergen load and anaphylaxis risk in sensitized individuals.

Recommendation. If you have pollen allergies, asthma, or any history of bee product reactions, do not combine these and seek medical advice before use. Stop immediately and seek care if swelling, hives, or breathing difficulty occur.

Sources (2)
  1. Lombardi C, et al. Anaphylaxis after ingestion of royal jelly and bee pollen. Journal of Investigational Allergology and Clinical Immunology, 1998.
  2. Leung R, Ho A, Chan J, et al. Royal jelly consumption and hypersensitivity in the community. Clinical and Experimental Allergy, 1997.

Stack Score

How this pair moves the number.

Effect on the composite score

If both Bee Pollen and Royal Jelly are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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