From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Berberine can lower glucose and may confound glucose interpretation if an unapproved metabolic peptide is used.
Mechanism. Potential additive or confusing metabolic effects.
Recommendation. Avoid unsupervised stacking; monitor glucose only under clinician care.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and HGH Fragment 176-191 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Stier H et al. AOD9604 overweight and obese subjects. J Endocrinol Metab. 2013.Needs sourceNo link