Supplement × Prescription·a caution·Emerging evidence
Berberine may inhibit CYP3A4 or P-glycoprotein and could increase itraconazole intolerance in susceptible patients.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Berberine may inhibit CYP3A4 or P-glycoprotein and could increase itraconazole intolerance in susceptible patients.
Mechanism. Potential transporter and CYP3A4 inhibition could increase azole exposure; evidence is limited but the interaction direction is plausible.
Recommendation. Avoid high-dose berberine unless the prescriber has reviewed the full medication list.
Effect on the composite score
If both Berberine and Itraconazole are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack