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Supplement × Supplement·a caution·Insufficient evidence

Berberine + MOTS-c

Caution Insufficient evidence

Berberine can lower glucose and may add to possible MOTS-c metabolic effects.

Source citations
1
Pair type
Caution
Evidence
Insufficient
Scope
Supplement × Supplement
Open the interaction checker → Read the methodology
From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Berberine and MOTS-c
Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Berberine can lower glucose and may add to possible MOTS-c metabolic effects.

Mechanism. Potential additive glucose-lowering.

Recommendation. Avoid combining in diabetes or hypoglycemia risk without clinician monitoring.

Stack Score

How it moves the number.

Effect on the composite score

If both Berberine and MOTS-c are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Lee C et al. MOTS-c metabolic homeostasis. Cell Metab. 2015.Needs sourceNo link

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.