Supplement × Supplement·a caution·Insufficient evidence

Alpha-Lipoic Acid + MOTS-c

Caution Insufficient evidence

Alpha-lipoic acid can improve insulin sensitivity and may increase hypoglycemia risk in a metabolic peptide stack.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Alpha-lipoic acid can improve insulin sensitivity and may increase hypoglycemia risk in a metabolic peptide stack.

Mechanism. Additive insulin-sensitizing effects.

Recommendation. Monitor glucose only in supervised settings; avoid self-use.

Stack Score

How it moves the number.

Effect on the composite score

If both Alpha-Lipoic Acid and MOTS-c are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Li H et al. MDP metabolic states meta-analysis. Front Endocrinol. 2024.Needs sourceNo link

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