From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Alpha-lipoic acid can improve insulin sensitivity and may increase hypoglycemia risk in a metabolic peptide stack.
Mechanism. Additive insulin-sensitizing effects.
Recommendation. Monitor glucose only in supervised settings; avoid self-use.
Stack Score
How it moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and MOTS-c are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Li H et al. MDP metabolic states meta-analysis. Front Endocrinol. 2024.Needs sourceNo link