From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Both may improve insulin resistance and can increase the chance of low-glucose symptoms when combined with diabetes medications or low calorie intake.
Mechanism. Complementary insulin-sensitizing and glucose-lowering pathways.
Recommendation. Monitor glucose symptoms and avoid adding both at full dose simultaneously when using glucose-lowering medication.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and Myo-Inositol & D-Chiro-Inositol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Fitz V et al. Inositol for PCOS systematic review. JCEM. 2024.Needs sourceNo link