NutriStack
Berberine and Vanadium, a caution.
Vanadium has insulin-mimetic glucose-lowering activity and berberine is a potent glucose-lowering compound, so combining them can additively reduce blood glucose and increase the risk of hypoglycemia.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Vanadium has insulin-mimetic glucose-lowering activity and berberine is a potent glucose-lowering compound, so combining them can additively reduce blood glucose and increase the risk of hypoglycemia.
Mechanism. Vanadium enhances insulin receptor signaling by inhibiting protein tyrosine phosphatases, while berberine activates AMP-activated protein kinase and improves insulin sensitivity, producing additive lowering of blood glucose.
Recommendation. Avoid combining without medical supervision. If used together, monitor blood glucose, especially when also taking antidiabetic medications, and watch for hypoglycemia symptoms.
Sources (2)
- Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008. PMID 18442638
- Thompson KH, Orvig C. Vanadium in diabetes: 100 years from Phase 0 to Phase I. Journal of Inorganic Biochemistry, 2006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Vanadium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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