NutriStack
Alpha-Lipoic Acid and Vanadium, a caution.
Vanadium acts as an insulin mimetic and alpha-lipoic acid improves insulin sensitivity and glucose uptake, so the pair can additively lower blood glucose and raise hypoglycemia risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and Vanadium
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Vanadium acts as an insulin mimetic and alpha-lipoic acid improves insulin sensitivity and glucose uptake, so the pair can additively lower blood glucose and raise hypoglycemia risk.
Mechanism. Vanadium enhances insulin receptor signaling via protein tyrosine phosphatase inhibition, while alpha-lipoic acid promotes GLUT4-mediated glucose uptake and improves insulin sensitivity, together amplifying glucose lowering.
Recommendation. Use together only with clinician oversight. Monitor blood glucose, particularly if taking insulin or other antidiabetic agents, and be alert for hypoglycemia.
Sources (2)
- Singh U, Jialal I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008. PMID 19019027
- Thompson KH, Orvig C. Vanadium in diabetes: 100 years from Phase 0 to Phase I. Journal of Inorganic Biochemistry, 2006
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Vanadium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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