NutriStack
Chromium and Vanadium, a caution.
Vanadium and chromium both have insulin-sensitizing, glucose-lowering activity, so combining them can produce additive reductions in blood glucose and risk of hypoglycemia, particularly in people on diabetes medication.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Vanadium and chromium both have insulin-sensitizing, glucose-lowering activity, so combining them can produce additive reductions in blood glucose and risk of hypoglycemia, particularly in people on diabetes medication.
Mechanism. Vanadium compounds mimic insulin by inhibiting protein tyrosine phosphatases and enhancing insulin receptor signaling, while chromium improves insulin receptor sensitivity; the combined effect can lower glucose further than either alone.
Recommendation. Avoid stacking unless supervised by a clinician. People taking antidiabetic drugs should monitor blood glucose closely and watch for signs of hypoglycemia.
Sources (2)
- Thompson KH, Orvig C. Vanadium in diabetes: 100 years from Phase 0 to Phase I. Journal of Inorganic Biochemistry, 2006
- Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr. 1998. PMID 9853533
Stack Score
How this pair moves the number.
Effect on the composite score
If both Chromium and Vanadium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
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