NutriStack
Alpha-Lipoic Acid and Chromium, a synergy.
Combining chromium with alpha-lipoic acid may improve insulin sensitivity and cellular glucose uptake more than either taken alone.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
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At a glance
- Substances
- Alpha-Lipoic Acid and Chromium
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Combining chromium with alpha-lipoic acid may improve insulin sensitivity and cellular glucose uptake more than either taken alone.
Mechanism. Chromium potentiates insulin receptor signaling via the low-molecular-weight chromium-binding substance (chromodulin), while alpha-lipoic acid increases AMPK activation and GLUT4 translocation, so the two support complementary steps of insulin-stimulated glucose uptake.
Recommendation. Reasonable to take together for glycemic support. If you use blood-glucose-lowering medication, monitor for additive lowering and discuss dosing with your clinician.
Sources (2)
- Vincent JB. The bioinorganic chemistry of chromium(III). Polyhedron. 2001
- Singh U, Jialal I. Alpha-lipoic acid supplementation and diabetes. Nutrition Reviews. 2008
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Chromium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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