NutriStack
Bisoprolol and Coenzyme Q10, a synergy.
Beta-blockers as a class inhibit mitochondrial CoQ10-dependent enzymes, contributing to fatigue and reduced exercise tolerance. CoQ10 100-200 mg/day can restore enzyme activity and may slightly lower blood pressure, complementing bisoprolol's effects in heart failure or hypertension.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Bisoprolol and Coenzyme Q10
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Beta-blockers as a class inhibit mitochondrial CoQ10-dependent enzymes, contributing to fatigue and reduced exercise tolerance. CoQ10 100-200 mg/day can restore enzyme activity and may slightly lower blood pressure, complementing bisoprolol's effects in heart failure or hypertension.
Mechanism. Beta-blockers inhibit CoQ10-dependent NADH-oxidase and succinate-oxidase in mitochondria, lowering ATP synthesis. Supplemental CoQ10 restores enzyme activity in cardiac and skeletal muscle.
Recommendation. Consider CoQ10 100-200 mg/day with food if you experience fatigue or exercise intolerance on bisoprolol. Monitor blood pressure since CoQ10 can produce a small additional drop.
Sources (2)
- Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Res Commun Chem Pathol Pharmacol. 1977;17(1):157-64. PMID 17892
- Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007;21(4):297-306. PMID 17287847
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bisoprolol and Coenzyme Q10 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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