NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Bisoprolol

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Bisoprolol is a highly cardioselective beta-1 blocker with proven mortality reduction in heart failure from the CIBIS-II trial. It has the highest beta-1 selectivity among available beta-blockers, making it better tolerated in patients with mild airway disease.

Evidence tier
Strong
Indexed sources
10 2013–2026
Interactions
0
Depletes
1 nutrient
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Bisoprolol is a highly cardioselective beta-1 blocker with proven mortality reduction in heart failure from the CIBIS-II trial. NutriStack rates the supporting evidence as strong. Common adult dosing is 1.25–20 mg once daily (heart failure: start 1.25 mg, target 10 mg; hypertension: 2.5–20 mg) (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete coq10. This profile indexes 10 sources.

What it's good for
  • Reduces mortality in heart failure (CIBIS-II trial)7,6
  • Highest beta-1 selectivity among beta-blockers4,5
  • Effective blood pressure and rate control8
  • Once-daily dosing
What to watch for
  • Bradycardia
  • Fatigue
  • Dizziness
  • Severe sinus bradycardia
  • Second- or third-degree heart block without pacemaker7

The bottom line

Evidence rating strong. Most-documented uses: reduces mortality in heart failure (cibis-ii trial), highest beta-1 selectivity among beta-blockers, effective blood pressure and rate control. 10 sources indexed (2013–2026), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Highly selective beta-1 adrenergic receptor antagonist. Reduces heart rate, myocardial contractility, and cardiac output. Decreases renin release. Highest beta-1/beta-2 selectivity ratio among clinically available beta-blockers (~75:1), reducing risk of bronchospasm and metabolic side effects.4,5

Class
Beta-1 Selective Adrenergic Blocker
Dosing

Dosing & protocol.

Common range
1.25–20 mg once daily (heart failure: start 1.25 mg, target 10 mg; hypertension: 2.5–20 mg) (as prescribed by your physician)
Recommended form
Oral tablet

Can be taken with or without food; approximately 80% bioavailability; minimal first-pass metabolism1

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

CoQ10

Mild

Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support.

Replace Coenzyme Q10Monitor Plasma CoQ10Onset Usually over months of chronic use
Safety

Full safety detail.

Side effects

  • Bradycardia
  • Fatigue
  • Dizziness
  • Headache
  • Cold extremities
  • Diarrhea
  • Nausea

Contraindications

  • Severe sinus bradycardia
  • Second- or third-degree heart block without pacemaker7
  • Cardiogenic shock
  • Decompensated heart failure7
  • Severe asthma or COPD
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

4

Randomized controlled trials

1

Reference material

5
FAQ

Common questions.

Quick answers about Bisoprolol, drawn from the data on this page.

What is Bisoprolol?

Bisoprolol is a highly cardioselective beta-1 blocker with proven mortality reduction in heart failure from the CIBIS-II trial. It has the highest beta-1 selectivity among available beta-blockers, making it better tolerated in patients with mild airway disease.

What is Bisoprolol used for?

Commonly cited benefits of Bisoprolol include: Reduces mortality in heart failure (CIBIS-II trial); Highest beta-1 selectivity among beta-blockers; Effective blood pressure and rate control; Once-daily dosing. NutriStack rates the overall evidence as strong.

What is a typical dose of Bisoprolol?

A typical adult dose of Bisoprolol is 1.25–20 mg once daily (heart failure: start 1.25 mg, target 10 mg; hypertension: 2.5–20 mg) (as prescribed by your physician). The commonly recommended form is Oral tablet. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Bisoprolol?

Reported side effects include bradycardia, fatigue, dizziness, headache, cold extremities, diarrhea. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Bisoprolol?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Bisoprolol in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.