NutriStack
Cannabis (THC-Dominant) and Latanoprost, a caution.
THC-dominant cannabis can temporarily lower intraocular pressure, but the effect is short-lived and is not a reliable substitute for latanoprost. Using cannabis around eye-pressure checks can also make pressure look better than it is during the rest of the day. This matters because glaucoma progression is often silent until vision loss is advanced.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Cannabis (THC-Dominant) and Latanoprost
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. THC-dominant cannabis can temporarily lower intraocular pressure, but the effect is short-lived and is not a reliable substitute for latanoprost. Using cannabis around eye-pressure checks can also make pressure look better than it is during the rest of the day. This matters because glaucoma progression is often silent until vision loss is advanced.
Mechanism. Latanoprost is a prostaglandin F2-alpha analog that lowers intraocular pressure mainly by increasing uveoscleral outflow. THC and related cannabinoids can lower intraocular pressure through cannabinoid-receptor pathways, but the effect is transient and accompanied by systemic CNS and cardiovascular effects.
Recommendation. Do not replace or skip latanoprost because cannabis seems to lower eye pressure. Tell your eye clinician if you use THC-dominant cannabis, especially before pressure checks or visual-field testing. Keep latanoprost dosing consistent and seek ophthalmology guidance for any plan to change glaucoma therapy.
Sources (3)
- Garway-Heath DF, Crabb DP, Bunce C, et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet. 2015;385(9975):1295-1304. PMID 25533656
- Novack GD. Cannabinoids for treatment of glaucoma. Curr Opin Ophthalmol. 2016;27(2):146-150. PMID 26840343
- Tomida I, Pertwee RG, Azuara-Blanco A. Cannabinoids and glaucoma. Br J Ophthalmol. 2004;88(5):708-713. PMID 15090428
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cannabis (THC-Dominant) and Latanoprost are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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