NutriStack
Cat's Claw and HIV Protease Inhibitors, a caution.
Cat's claw inhibits CYP3A4 more potently than ketoconazole in vitro. Documented interactions with atazanavir, ritonavir, saquinavir.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Cat's Claw and HIV Protease Inhibitors
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Cat's claw inhibits CYP3A4 more potently than ketoconazole in vitro. Documented interactions with atazanavir, ritonavir, saquinavir.
Mechanism. Potent CYP3A4 inhibition plus PXR activation creates complex drug metabolism effects.
Recommendation. Avoid concurrent use.
Sources (2)
- Cat's claw CYP3A4 inhibition PMID 10969720
- Cat's claw protease inhibitor interaction PMID 18712519
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cat's Claw and HIV Protease Inhibitors are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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